Ukuphepha kwe-PRP Nokuthembeka

Ithembeke kangakanani i-PRP?

I-PRP yenza ngokuwohloka kwezinhlayiya ze-alpha kumaplatelet, aqukethe izici ezithile zokukhula.I-PRP kufanele ilungiswe esimweni se-anticoagulant futhi kufanele isetshenziswe ekuxhunyweni, ama-flaps, noma amanxeba kungakapheli imizuzu eyi-10 yehlule.

Njengoba ama-platelet enziwa asebenze inqubo yokujiyisa, izici zokukhula zifihliwe kusuka kuseli ngolwelwesi lwamaseli.Kule nqubo, izinhlayiya ze-alpha zihlangana kulwelwesi lwamaseli eplatelet, futhi izici zokukhula kwamaprotheni ziqeda isimo se-bioactive ngokwengeza amaketanga aseceleni e-histone nama-carbohydrate kulawa maprotheni.

Ucwaningo luye lwabonisa ukuthi amangqamuzana e-mesenchymal stem abantu abadala, ama-osteoblasts, ama-fibroblasts, amaseli e-endothelial, namaseli e-epidermal aveza ama-cell membrane receptors ezicini zokukhula ku-PRP.Lawa ma-receptors e-transmembrane nawo adala ukuthi kusebenze amaprotheni ophawu lwangaphakathi angaphakathi aholela ekukhulumeni (ukuvulwa) kokulandelana kwezakhi zofuzo ezijwayelekile zamangqamuzana, njengokwanda kwamaseli, ukwakheka kwe-matrix, ukwakheka kwe-osteoid, ukuhlanganiswa kwe-collagen, njll.

Ngakho-ke, izici zokukhula kwe-PRP azilokothi zingene esitokisini noma ku-nucleus yayo, aziwona ama-mutagenic, zivele zisheshise ukugqugquzela ukuphulukiswa okujwayelekile.

Ngemva kokuqhuma kokuqala kwezici zokukhula ezihambisana ne-PRP, ama-platelet ahlangana futhi akhiphe izici ezengeziwe zokukhula ezinsukwini ezingu-7 ezisele zesikhathi sokuphila kwawo.Lapho ama-platelet esephelile futhi efile, ama-macrophage afinyelela esifundeni ngemithambo yegazi evuselelwe i-platelet akhulela ngaphakathi ukuze abambe iqhaza lokulawula ukuphulukiswa kwesilonda ngokufihla ezinye zezinto ezifanayo zokukhula kanye nezinye.Ngakho, inani lama-platelet ku-graft, inxeba, noma ihlule legazi elixhunywe ku-flap linquma ukuthi isilonda saphola ngokushesha kangakanani.I-PRP ivele yengeze kuleyo nombolo.

I-1）I-PRP ingathuthukisa amaseli e-bone progenitor ku-host host bone kanye ne-bone grafts futhi ikhuthaze ukwakheka kwamathambo.I-PRP futhi iqukethe izici ezihlukahlukene zokukhula, ezingakhuthaza ukuhlukaniswa kwamaseli nokuhlukaniswa nokukhuthaza ukulungiswa komzimba.

2）Ama-leukocyte ku-PRP angathuthukisa ikhono lokulwa nokutheleleka kwesayithi elimele, asize umzimba ukuthi ukhiphe izicubu ze-necrotic, futhi usheshise ukulungiswa kokulimala.

I-3）I-PRP iqukethe inani elikhulu le-fibrin, engakha inkundla yokulungisa engcono yokulungisa umzimba futhi ishwabe amanxeba ngesikhathi esisodwa.

Ingabe i-PRP iphephile ngempela futhi iyasebenza?

1) Imikhiqizo yegazi ezenzakalelayo

Inombolo enkulu yedatha yokuhlola ibonise ukuthi i-PRP ingabonisa ukuphepha nokuthembeka kwayo ekwelashweni okuningi.Njengomkhiqizo wegazi we-autologous, i-PRP igwema ngokuphumelelayo ukwenqatshwa nokudluliselwa kwezifo okubangelwa ukusetshenziswa kwegazi le-allogeneic ngesikhathi sokwelashwa.

2）Isiqalisi se-coagulation siphephile

I-PRP isebenzisa i-thrombin yezinkomo njengesiqalisi sokuhlanganisa, evumela ukukhishwa kwe-PRP kanye nezinqubo zokuhlinzwa.I-thrombin yezinkomo esetshenzisiwe icutshungulwa ngokushisa futhi ayibangeli izifo.Futhi ngenxa yokuthi inani le-thrombin yezinkomo elisetshenzisiwe lincane kakhulu, alingeni emzimbeni futhi libangele ukwenqatshwa ngesikhathi sokusetshenziswa.

3) Umkhiqizo uphephile futhi uyasebenza

Amasu e-Aseptic asetshenziswa ekulungiseleleni i-PRP, okuholela ekwakhekeni kwegazi okungabangeli izinkinga zokutheleleka futhi angabangeli ukukhula kwamagciwane.

(Okuqukethwe yile ndatshana kuphrintwe kabusha, futhi asinikezeli nganoma yisiphi isiqinisekiso esicacile noma esishiwoyo sokunemba, ukwethembeka noma ukuphelela kokuqukethwe okuqukethwe kulesi sihloko, futhi asinasibopho ngemibono yalesi sihloko, sicela uqonde.)