I-Platelet-Rich Plasma (PRP) ye-Androgenetic Alopecia (AGA)

I-Androgenic alopecia (AGA), uhlobo oluvame kakhulu lokuqothuka kwezinwele, ukuqothuka kwezinwele okuqhubekayo okuqala ebusheni noma ekuthombeni sekwephuzile.Ukwanda kwabesilisa ezweni lami cishe kungama-21.3%, kanti abesifazane bangama-6.0%.Nakuba ezinye izazi ziye zahlongoza iziqondiso zokuxilongwa nokwelashwa kwe-androgenetic alopecia e-China esikhathini esidlule, zigxile kakhulu ekuxilongweni nasekwelashweni kwe-AGA, kanti ezinye izindlela zokwelapha ziyashoda.Eminyakeni yakamuva, ngokugcizelela ekwelashweni kwe-AGA, ezinye izindlela zokwelapha ezintsha ziye zavela.

I-Etiology kanye ne-Pathogenesis

I-AGA iwufuzo olwandulela i-polygenic recessive disorder.Izinhlolovo zasekhaya ze-epidemiological zikhombisa ukuthi ama-53.3% -63.9% eziguli ze-AGA anomlando womndeni, futhi uhlu lozalo luphakeme kakhulu kunomugqa womama.Izifundo zamanje zokulandelana kofuzo oluphelele kanye nemephu zikhombe izakhi zofuzo ezimbalwa ezithintekayo, kodwa izakhi zazo zofuzo ze-pathogenic azikakahlonzwa.Ucwaningo lwamanje lubonisa ukuthi i-androgens idlala indima ebalulekile ku-pathogenesis ye-AGA;ezinye izici ezihlanganisa ukuvuvukala okuzungeze i-follicle yezinwele, ukunyuka kwengcindezi yokuphila, ukushuba nokukhathazeka, nokuphila okungalungile nokudla kungandisa izimpawu ze-AGA.I-Androgens emadodeni ikakhulukazi iphuma ku-testosterone ekhishwa ngamasende;ama-androgens kwabesifazane ikakhulukazi avela ekuhlanganisweni kwe-adrenal cortex kanye nenani elincane lokukhishwa kwamaqanda, i-androgen ngokuyinhloko i-androstenediol, engashintshwa ibe yi-testosterone ne-dihydrotestosterone.Nakuba i-androgens iyisici esibalulekile ku-pathogenesis ye-AGA, amazinga e-androgen ajikelezayo cishe kuzo zonke iziguli ze-AGA agcinwa emazingeni avamile.Ucwaningo luye lwabonisa ukuthi umphumela we-androgens kuma-follicle wezinwele ezithintekayo uyanda ngenxa yokwanda kwe-androgen receptor gene expression kanye/noma ukubonakaliswa okwandisiwe kohlobo lwe-II 5α reductase gene ezinhlakeni zezinwele endaweni ye-alopecia.Ku-AGA, amangqamuzana engxenye ye-dermal of follicles yezinwele ezithintekayo aqukethe uhlobo oluthile lwe-II 5α reductase, olungaguqula i-androgen testosterone ezungeza endaweni esegazini ibe yi-dihydrotestosterone ngokubophezela ku-intracellular androgen receptor.Ukuqala uchungechunge lokusabela okuholela ekwenziweni okuncane okuqhubekayo kwezinhlayiya zezinwele nokuqothuka kwezinwele ukuya empandleni.

Ukubonakaliswa Komtholampilo kanye Nezincomo Zokwelashwa

I-AGA iwuhlobo lwe-alopecia olungashayi izibazi oluvame ukuqala phakathi nenkathi yokuthomba futhi ibonakala ngokuncipha okuqhubekayo kobubanzi bezinwele, ukulahlekelwa ukuminyana kwezinwele, kanye ne-alopecia kuze kube amazinga ahlukahlukene empandla, ngokuvamile ahambisana nezimpawu zokwanda kokuphuma kwamafutha ekhanda.

Isicelo se-PRP

Ukuhlushwa kwe-platelet kulingana nokugxila kwe-4-6 izikhathi zokuhlushwa kwe-platelet egazini lonke.Uma i-PRP isicushiwe, ama-α granules kuma-platelet azokhulula inani elikhulu lezici zokukhula, okuhlanganisa i-platelet-derived growth factor, ukuguqula isici sokukhula-β, i-insulin-like growth factor, i-epidermal growth factor kanye ne-vascular endothelial growth factor, njll. yokugqugquzela ukukhula kwe-follicle yezinwele, kodwa indlela ethile yokusebenza ayicacile ngokugcwele.Ukusetshenziswa ukujova i-PRP endaweni endaweni ye-dermis ye-scalp endaweni ye-alopecia, kanye ngenyanga, futhi imijovo eqhubekayo izikhathi ezi-3 kuya kwezi-6 ingabona umphumela othile.Nakuba izifundo ezihlukahlukene zemitholampilo ekhaya nakwamanye amazwe ziye zaqinisekisa kusengaphambili ukuthi i-PRP inomphumela othile ku-AGA, ayikho indinganiso efanayo yokulungiswa kwe-PRP, ngakho-ke izinga elisebenzayo lokwelashwa kwe-PRP alifani, futhi lingasetshenziswa njengesiza. kusho ukwelashwa kwe-AGA kulesi sigaba.

(Okuqukethwe yile ndatshana kuphrintwe kabusha, futhi asinikezeli nganoma yisiphi isiqinisekiso esicacile noma esishiwoyo sokunemba, ukwethembeka noma ukuphelela kokuqukethwe okuqukethwe kulesi sihloko, futhi asinasibopho ngemibono yalesi sihloko, sicela uqonde.)