I-Platelet Rich Plasma (PRP)
I-PRP iye yakhanga ukunaka ngoba iqukethe izici ezihlukahlukene zokukhula, futhi isetshenziswa kabanzi ekuhlinzeni i-maxillofacial, orthopedics, plastic surgery, ophthalmology kanye neminye imikhakha.Ngo-2006, u-Uebel et al.okokuqala wazama ukuhlehlisa amayunithi e-follicular ukuze atshalwe kabusha nge-PRP futhi waqaphela ukuthi uma kuqhathaniswa nendawo yokulawula isikhumba, indawo yokufakelwa izinwele eziphathwe nge-PRP yasinda kumayunithi we-follicular angu-18.7 / cm2, kuyilapho iqembu lokulawula lisinda kumayunithi e-follicular angu-16.4./cm2, ukuminyana kukhuphuke ngo-15.1%.Ngakho-ke, kucatshangelwa ukuthi izici zokukhula ezikhishwe ama-platelet zingase zisebenze kuma-stem cells we-hair follicle bulge, zikhuthaze ukuhlukaniswa kwamangqamuzana e-stem futhi zikhuthaze ukwakheka kwemithambo yegazi emisha.
Ngo-2011, uTakikawa et al.kusetshenziswe i-saline evamile, i-PRP, i-heparin-protamine microparticles ehlanganiswe ne-PRP (PRP & D/P MPs) kumjovo ongaphansi kwesikhumba weziguli ze-AGA ukusetha izilawuli.Imiphumela yabonisa ukuthi indawo ephambanayo yezinwele eqenjini le-PRP kanye neqembu le-PRP&D/P MPs yanda kakhulu, imicu ye-collagen kanye nama-fibroblasts ezimpandeni zezinwele kwanda ngaphansi kwe-microscope, kanye nemithambo yegazi ezungeze izimpande zezinwele zanda.
I-PRP icebile ezicini zokukhula ezitholakala ku-platelet.Lawa maprotheni abalulekile alawula ukufuduka kwamangqamuzana, okunamathiselwe, ukwanda, nokuhlukaniswa, akhuthaze ukuqoqwa kwe-matrix engaphandle kwe-extracellular, futhi izici eziningi zokukhula zikhuthaza ukukhula kwezinwele: izici zokukhula ku-PRP zisebenzisana nezinwele zezinwele.Ukuhlanganiswa kwamangqamuzana e-stem cell kubangela ukwanda kwezinhlayiya zezinwele, kukhiqize amayunithi e-follicular, futhi kukhuthaze ukuvuselelwa kwezinwele.Ngaphezu kwalokho, ingenza kusebenze ukusabela kwe-cascade engezansi futhi ikhuthaze i-angiogenesis.
Isimo samanje se-PRP ekwelapheni i-AGA
Akusekho ukuvumelana ngendlela yokulungiselela kanye nesici sokuthuthukisa i-platelet ye-PRP;izinhlobo zokwelapha ziyahlukahluka enanini lokwelashwa, isikhathi sokuphumula, isikhathi sokuhlehla, indlela yomjovo, kanye nokuthi izidakamizwa ezihlanganisiwe ziyasetshenziswa yini.
UMapar et al.kuhlanganisa iziguli zesilisa eziyi-17 ezinesiteji IV kuya ku-VI (indlela yesiteji ye-Hamilton-Norwood), futhi imiphumela ayizange ibonise umehluko phakathi kwemijovo ye-PRP ne-placebo, kodwa ucwaningo lwenze imijovo emi-2 kuphela, futhi inani lokwelashwa lalincane kakhulu.Imiphumela ivulekele imibuzo.;
U-Gkini et al uthole ukuthi iziguli ezinesiteji esiphansi zibonise ukusabela okuphezulu ekwelapheni kwe-PRP;lo mbono uqinisekiswe yi-Qu et al, ehlanganisa iziguli ze-51 zesilisa kanye ne-42 zesifazane ezinesiteji II-V emadodeni kanye ne-I kwabesifazane ~ Isiteji III (isiteji yi-Hamilton-Norwood ne-Ludwig indlela yesiteji), imiphumela ibonisa ukuthi ukwelashwa kwe-PRP umehluko ophawulekayo wezibalo ezigulini ezinezigaba ezahlukene zamadoda nabesifazane, kodwa ukusebenza kwesiteji esiphansi kanye nesiteji esiphezulu kungcono, ngakho-ke abacwaningi batusa i-II, i-Stage III iziguli zesilisa kanye neziguli zesifazane zesiteji I zaphathwa nge-PRP.
Isici Sokucebisa Esiphumelelayo
Umehluko wezindlela zokulungiselela ze-PRP ocwaningweni ngalunye uholele ekugoqweni okuhlukile kokunothisa kwe-PRP ocwaningweni ngalunye, iningi lazo laligxilwe phakathi kwe-2 ne-6 izikhathi.I-platelet degranulation ikhulula inani elikhulu lezici zokukhula, ilawula ukufuduka kwamangqamuzana, okunamathiselwe, ukwanda nokuhlukaniswa, ivuselela ukukhula kwamangqamuzana ezinwele ze-follicle, i-tissue vascularization, futhi ikhuthaze ukuqoqwa kwe-matrix ye-extracellular.Ngesikhathi esifanayo, indlela ye-microneedling kanye ne-laser therapy ene-low-energy ibhekwa njenge-Ikhiqiza ukulimala kwezicubu ezilawulwayo futhi ivuselela inqubo yemvelo ye-platelet degranulation, enquma ikhwalithi yomkhiqizo we-PRP incike emsebenzini wayo wezinto eziphilayo.Ngakho-ke, kubalulekile ukuhlola ukugxila okusebenzayo kwe-PRP.Ezinye izifundo zikholelwa ukuthi i-PRP enezikhathi zokucebisa izikhathi ezingu-1-3 isebenza kangcono kune-fold yokucebisa ephakeme, kodwa u-Ayatollahi et al.wasebenzisa i-PRP ngokuhlushwa okucebile kwezikhathi ze-1.6 zokwelashwa, futhi imiphumela yabonisa ukuthi ukwelashwa kweziguli ze-AGA kwakungasebenzi, futhi kukholelwa ukuthi i-PRP Ukugxila okuphumelelayo kufanele kube izikhathi ze-4 ~ 7.
Inombolo Yokwelashwa, Isikhathi Sekhefu kanye Nesikhathi Sokuphumula
Izifundo zikaMapar et al.kanye noPuig et al.bobabili bathole imiphumela engemihle.Inombolo yezokwelapha ze-PRP kulezi zivumelwano ezimbili zocwaningo kwakuyizikhathi ze-1 ne-2, ngokulandelanayo, ezaziphansi kunezinye izifundo (ikakhulukazi izikhathi ze-3-6).UPicard et al.bathole ukuthi ukusebenza kahle kwe-PRP kufinyelele umvuthwandaba ngemuva kokwelashwa kwe-3 kuya kwe-5, ngakho bakholelwa ukuthi ukwelashwa okungaphezulu kwe-3 kungase kudingeke ukuze kuthuthukiswe izimpawu zokuqothuka kwezinwele.
Ukuhlaziywa kwamaGupta noCarviel kwathola ukuthi iningi lezifundo ezikhona zinezikhawu zokwelashwa zenyanga engu-1, futhi ngenxa yenani elilinganiselwe lezifundo, imiphumela yokwelashwa ngemijovo yanyanga zonke ye-PRP ayizange iqhathaniswe namanye amafrikhwensi omjovo, njengomjovo wamasonto onke we-PRP.
Ucwaningo olwenziwa nguHausauer noJones [20] lubonise ukuthi izifundo ezithola imijovo yanyanga zonke zinentuthuko enkulu ekubalweni kwezinwele uma kuqhathaniswa nemvamisa yemijovo njalo ezinyangeni ze-3 (P <0.001);Schiavone et al.[21] waphetha ngokuthi, Ukwelashwa kufanele kuphindwe izinyanga ezingu-10 kuya kwezingu-12 ngemva kokuphela kwenkambo yokwelashwa;Owezizwe et al.kulandelwe iminyaka emi-2, isikhathi eside kakhulu sokulandelela phakathi kwazo zonke izifundo, futhi kwatholakala ukuthi ezinye iziguli ziphinde zabuyela emuva ezinyangeni ezingu-12 (izimo ezingu-4/20), futhi ezigulini eziyi-16 Izimpawu zibonakala kakhulu ezinyangeni.
Ekulandeleni kuka-Sclafani, kwatholakala ukuthi ukusebenza kahle kweziguli kwehle kakhulu ezinyangeni ezi-4 ngemva kokuphela kwenkambo yokwelashwa.UPicard et al.wabhekisela emiphumeleni futhi wanikeza iseluleko sokwelashwa esihambisanayo: ngemva kwesikhawu esivamile sokwelashwa oku-3 kwenyanga engu-1, ukwelashwa kufanele kwenziwe njalo izikhathi ezi-3.Ukwelashwa okunamandla kwanyanga zonke.Kodwa-ke, u-Sclafani akazange achaze isilinganiso sokuthuthukisa i-platelet yamalungiselelo asetshenziselwa inqubo yokwelapha.Kulolu cwaningo, u-8-9 ml wamalungiselelo e-fibrin ecebile ngeplatelet alungiswa kusuka ku-18 ml wegazi le-peripheral (i-PRP ekhishiwe yengezwa kushubhu yevacuum ye-CaCl2, futhi i-fibrin glue yafakwa ku-fibrin glue. umjovo ngaphambi kokwakheka) , sikholelwa ukuthi ukugoqa okucebile kwama-platelet kulokhu kulungiselelwa kungase kube kude nokwanele, futhi kudingeka ubufakazi obengeziwe bokusekela.
Indlela Yokujova
Izindlela eziningi zokujova umjovo we-intradermal kanye nomjovo ongaphansi kwesikhumba.Abacwaningi baxoxe ngomthelela wendlela yokuphatha emthelela wokwelapha.UGupta noCarviel bancome umjovo ongaphansi kwesikhumba.Abanye abacwaningi basebenzisa umjovo we-intradermal.Umjovo we-Intradermal ungabambezela ukungena kwe-PRP egazini, unciphise izinga lokugayeka kokudla, unwebe isikhathi sesenzo sendawo, futhi ukwandise ukugqugquzelwa kwedermis ukukhuthaza ukukhula kwezinwele.nokujula akufani.Sincoma ukuthi indlela yomjovo we-Nappage kufanele isetshenziswe ngokuqinile lapho kwenziwa imijovo ye-intradermal ukuze ikhiphe ithonya lomehluko womjovo, futhi sincoma ukuthi iziguli ziphuce izinwele zazo zibe zimfushane ukuze zibheke ukuqondiswa kwezinwele, futhi zilungise i-engeli yokufaka inaliti ngokufanele ngokusho kwayo. isiqondiso sokukhula ukuze ithiphu yenaliti ifinyelele eduze kwe-follicle yezinwele, ngaleyo ndlela ikhulise ukugxila kwe-PRP yendawo ku-follicle yezinwele.Lezi ziphakamiso ezimayelana nezindlela zomjovo zingezereferensi kuphela, njengoba lungekho ucwaningo oluqhathanisa ngokuqondile izinzuzo nezingozi zezindlela ezihlukahlukene zokujova.
Inhlanganisela yokwelapha
Jha et al.isetshenziswe i-PRP ehlanganiswe ne-microneedling kanye ne-5% yokwelapha ehlanganisiwe ye-minoxidil ukuze ibonise ukusebenza kahle kokubili kobufakazi obuhlosiwe kanye nokuzihlola kwesiguli.Sisabhekene nezinselele ekumiseni imishanguzo ye-PRP.Nakuba izifundo eziningi zisebenzisa izindlela ezisezingeni eliphezulu nezokulinganisa ukuze kuhlolwe ukuthuthukiswa kwezimpawu ngemva kokwelashwa, njengokubala izinwele ezibulalayo, ukubala kwezinwele ze-vellus, ukubala kwezinwele, ukuminyana, ukujiya, njll., izindlela zokuhlola ziyahlukahluka kakhulu;ngaphezu kwalokho, ukulungiswa kwe-PRP Ayikho indinganiso efanayo ngokwendlela, ukwengeza i-activator, isikhathi se-centrifugation nesivinini, ukuhlushwa kweplatelet, njll;izindlela zokwelapha ziyahlukahluka enanini lokwelashwa, isikhathi sokuphumula, isikhathi sokuhlehla, indlela yomjovo, nokuthi kuhlanganiswe yini imithi;ukukhethwa kwamasampula ocwaningweni akukona Ukuhlelwa ngokweminyaka, ubulili, kanye nezinga le-alopecia kuqhubekisele ukufiphalisa ukuhlolwa kwemiphumela yokwelapha ye-PRP.Ngokuzayo, izifundo ezizilawulayo ezinamasampula amakhulu zisadingeka ukuze kucaciswe imingcele yokwelashwa ehlukahlukene, nokuhlaziywa okwengeziwe okunestratified kwezici ezifana neminyaka yesiguli, ubulili, kanye nezinga lokulahlekelwa izinwele kungathuthukiswa kancane kancane.
(Okuqukethwe yile ndatshana kuphrintwe kabusha, futhi asinikezeli nganoma yisiphi isiqinisekiso esicacile noma esishiwoyo sokunemba, ukwethembeka noma ukuphelela kokuqukethwe okuqukethwe kulesi sihloko, futhi asinasibopho ngemibono yalesi sihloko, sicela uqonde.)
Isikhathi sokuthumela: Aug-02-2022