Imijovo emibili noma emine ye-plasma ecebile ngeplatelet edolweni le-osteoarthritis ayizange iguqule ama-synovial biomarkers, kodwa futhi yathuthukisa imiphumela yomtholampilo.
Ngokusho kokuhlolwa kochwepheshe bemboni efanele, baqhathanisa imijovo emibili nemine ye-intra-articular ye-plasma ecebile ngeplatelet (PRP) ngokuphathelene nezinguquko kuma-synovial cytokines kanye nemiphumela yomtholampilo.Iziguli ezingu-125 ezine-knee osteoarthritis (OA) zithole imijovo ye-PRP njalo emavikini angu-6.Ngaphambi komjovo ngamunye we-PRP, izifiso ze-synovial fluid zaqoqwa ukuze kufundwe.Iziguli zahlukaniswa zaba imijovo emibili noma emine ye-PRP ye-intra-articular (amaqembu A no-B, ngokulandelana).Izinguquko kuma-synovial biomarker ziqhathaniswa namazinga ayisisekelo kuwo womabili amaqembu, futhi imiphumela yomtholampilo yahlolwa kwaze kwaba unyaka owodwa.
Iziguli ezingamashumi ayisishiyagalolunye nane eziqede ukuqoqwa kwe-synovial fluid zifakwe ekuhlolweni kokugcina, i-51 eqenjini A kanye ne-43 eqenjini B. Kwakungekho umehluko eminyakeni yobudala, ubulili, inkomba yesisindo somzimba (BMI), kanye nebanga le-OA ye-radiographic.Isilinganiso se-platelet count kanye nokubala kwamangqamuzana egazi amhlophe ku-PRP kwakuyi-430,000/µL kanye ne-200/µL, ngokulandelana. Ama-cytokines avuthayo e-Synovial (IL-1β, IL-6, IA-17A, ne-TNF-α), ama-cytokines aphikisana nokuvuvukala (IL -4, IL-10, IL-13, kanye ne-IL-1RA) bezingashintshiwe, kanye ne-Group Factors (TGF-B1, VEGF, PDGF-AA kanye ne-PDGF-BB) yayisezingeni eliphansi futhi phakathi kwamaviki angu-6 kuQembu A kanye namaviki angu-18. kuQembu B.
Imiphumela yomtholampilo kuwo womabili amaqembu ithuthuke kakhulu kusukela emavikini e-6, kuhlanganise ne-Visual Analog Scale (VAS), Izilinganiso Zomphumela Obikiwe Ngesiguli [ama-PROM;I-Western Ontario kanye ne-McMaster Universities Osteoarthritis (WOMAC) Inkomba kanye neFomu Elifushane-12 (SF-12)], izinyathelo ezisekelwe ekusebenzeni [ama-PBM;isikhathi sokuvuka (TUG), ukuhlolwa kwe-5 ukuhlala-stand (5 × SST), nokuhlolwa kwemizuzu engu-3 yokuhamba (i-3-minute WT)].Ekuphetheni, i-2 noma i-4 imijovo ye-intra-articular ye-PRP njalo emavikini e-6 emadolweni. I-OA ayizange ibonise izinguquko kuma-synovial cytokines kanye nezici zokukhula, kodwa futhi yathuthukisa imiphumela yomtholampilo kusukela emavikini angu-6 kuya onyakeni ongu-1.
Isikhathi sokuthumela: Mar-03-2022